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Monday, November 29, 2021
United KingdomPostdoctoral Scientist in Leukaemia Biology

Postdoctoral Scientist in Leukaemia Biology

University of Oxford – Radcliffe Department of Medicine

For an aggressive and ambitious postdoctoral scientist, an exciting opportunity emerged to join Professor Paresh Vyas and Professor Irene Roberts of the MRC Wesel Institute of Molecular Medicine (WIMM). You will work in the Vyas laboratory and will work with Professors Vyas and Roberts and other research groups at WIMM.

Vyas and Roberts laboratories are world leaders in the biological research of acute myeloid leukemia using pediatric leukemia as a model. We focus on myeloid leukemia in children with Down syndrome, whose incidence of leukemia has increased 150-fold. Through comprehensive research on genetics and functional studies (including CRISPR-based screening and targeted loss of function studies combined with single-cell biology) in primary patient samples and in vivo models, successful applicants will now analyze how multiple leukemia mutations are Synergistically interfere with the differentiation of blood stem cells and progenitor cells, with the aim of understanding fundamental principles of how genetic and epigenetic change causes arises leukaemia and that will provide a platform for rational therapy.

You will hold a PhD (or near to completion: thesis submitted at time of application) in leukaemia biology, the study of haematopoiesis or transcription factor function. You will have laboratory experience in FACS analysis and sorting, CRISPR, cell culture, single cell biology, working with in vivo models and computational experience in analysis of transcriptomic and epigenetic datasets. A strong publication record in high-impact peer-reviewed journals is a prerequisite, as well as the ability to work independently and as part of a team. You will have excellent communication and organisational skills, with the ability to manage and independently drive, innovate and complete your own research and associated activities.

This post is fixed term until 10/01/2024, funded by Blood Cancer UK.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12 noon on Monday 06 December 2021.

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